Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
USERS' SCORE
Good
Based on 51 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
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9
We sought to determine the effectiveness of Curcuma longa extract, commonly known as turmeric, in alleviating knee pain associated with osteoarthritis. Our investigation focused on randomized controlled trials that compared turmeric extract with placebo, analyzing data from notable databases like PubMed and Cochrane Library through April 2021.
In total, we reviewed 10 trials encompassing 783 patients. The outcomes of our analysis were quite promising. We found that patients taking Curcuma longa experienced significantly greater relief from pain and improved overall function compared to those given a placebo. Notably, the measures used to assess pain and functionality showed results that exceeded the minimum clinically important differences, meaning that the improvements were not just statistically significant but also meaningful in real life.
This evidence suggests that incorporating turmeric extract into treatment plans may offer substantial benefits for those suffering from knee osteoarthritis. However, we must acknowledge that the studies we reviewed exhibited some variability, indicating a need for further high-quality research with larger participant groups to corroborate our findings on turmeric’s effectiveness.
In total, we reviewed 10 trials encompassing 783 patients. The outcomes of our analysis were quite promising. We found that patients taking Curcuma longa experienced significantly greater relief from pain and improved overall function compared to those given a placebo. Notably, the measures used to assess pain and functionality showed results that exceeded the minimum clinically important differences, meaning that the improvements were not just statistically significant but also meaningful in real life.
This evidence suggests that incorporating turmeric extract into treatment plans may offer substantial benefits for those suffering from knee osteoarthritis. However, we must acknowledge that the studies we reviewed exhibited some variability, indicating a need for further high-quality research with larger participant groups to corroborate our findings on turmeric’s effectiveness.
Read More
9.5
We aimed to understand how curcumin, a compound found in turmeric, impacts knee pain in individuals suffering from osteoarthritis (OA). Using various databases, we gathered and analyzed data from multiple meta-analyses that included randomized controlled trials focused on curcumin's effects on OA symptoms up to September 2023.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
Read More
Most Useful Reviews
9
Inflammation relief
87 people found this helpful
Long-term use of curcumin has effectively relieved my knee pain and inflammation post-surgery.
Read More
9
Natural anti-inflammatory
47 people found this helpful
Curcumin is a powerful natural anti-inflammatory that has helped me manage knee pain. Its effects on various inflammatory conditions, including arthritis and more, are impressive. A dosage of 1-1.5 grams is typically effective for pain relief.
Read More
9
Remarkable improvement
32 people found this helpful
I've been on curcumin for six months, and it has remarkably alleviated my knee pain. Initially, I struggled to walk, but after three months, my knee pain lessened significantly. I now take 2g daily, and I've reduced my other medications. Curcumin has made a considerable difference in my life.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
- All Researches
9.5
We aimed to understand how curcumin, a compound found in turmeric, impacts knee pain in individuals suffering from osteoarthritis (OA). Using various databases, we gathered and analyzed data from multiple meta-analyses that included randomized controlled trials focused on curcumin's effects on OA symptoms up to September 2023.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
Read More
9
Topical curcumin gel effectiveness
We conducted a study to explore the effectiveness of a unique topical gel infused with curcumin, a key ingredient in turmeric, for treating knee osteoarthritis. This innovative gel utilizes a self-nano-emulsifying organogel system, which allows for better delivery of curcumin, a compound known for its challenging solubility and stability issues.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
Read More
9
Turmeric improves knee osteoarthritis
Our study focused on the impact of a specific combination of polyphenolic supplements, including turmeric, on knee pain for individuals with osteoarthritis. We conducted a randomized controlled trial with 60 participants, half of whom received the polyphenolic supplement featuring turmeric, rosemary extract, and resveratrol, while the other half received a placebo.
Over the course of 12 weeks, those taking the polyphenol supplement reported significantly reduced pain levels and improved physical functionality. The data was collected using validated questionnaires, demonstrating clearer benefits in this group compared to those on the placebo.
Notably, we observed that the polyphenol supplement also helped reduce systemic inflammation, which could be a key factor in easing knee pain. This suggests that turmeric, as part of the supplement, may play a beneficial role in managing not just pain, but also the overall quality of life for those suffering from knee osteoarthritis.
Over the course of 12 weeks, those taking the polyphenol supplement reported significantly reduced pain levels and improved physical functionality. The data was collected using validated questionnaires, demonstrating clearer benefits in this group compared to those on the placebo.
Notably, we observed that the polyphenol supplement also helped reduce systemic inflammation, which could be a key factor in easing knee pain. This suggests that turmeric, as part of the supplement, may play a beneficial role in managing not just pain, but also the overall quality of life for those suffering from knee osteoarthritis.
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9
We studied the effects of curcumin, a compound in turmeric, alongside swimming to see how this combination could help alleviate knee pain caused by osteoarthritis (OA). In our research with rats, we set up five groups, with some getting the treatment and others serving as a control.
After injecting a substance that induces OA, we began a daily swimming regimen for certain groups and provided them with oral curcumin over four weeks. This combination proved to be the most effective in reducing pain and stiffness in the joints.
Not only did we notice improvement in the rats' discomfort, but there were also positive changes seen in their joint health when examined under a microscope. We observed a decrease in markers of inflammation, suggesting that the dual treatment could provide a more effective path for managing knee pain in osteoarthritis patients.
Overall, this research highlights the potential benefits of combining curcumin with physical activity like swimming for easing knee pain due to OA.
After injecting a substance that induces OA, we began a daily swimming regimen for certain groups and provided them with oral curcumin over four weeks. This combination proved to be the most effective in reducing pain and stiffness in the joints.
Not only did we notice improvement in the rats' discomfort, but there were also positive changes seen in their joint health when examined under a microscope. We observed a decrease in markers of inflammation, suggesting that the dual treatment could provide a more effective path for managing knee pain in osteoarthritis patients.
Overall, this research highlights the potential benefits of combining curcumin with physical activity like swimming for easing knee pain due to OA.
Read More
9
In our analysis, we investigated how a blend of several natural ingredients, including turmeric (CurQlife, curcumin), might alleviate knee pain in individuals suffering from osteoarthritis. Our study focused on the effects of this combination of nutraceuticals, known as Clagen™, which also includes native type 2 collagen, hyaluronic acid, and other supportive components.
We enrolled 100 patients with knee osteoarthritis and monitored their progress over two months. At the end of this period, we noted a significant reduction in pain levels, as evidenced by improved Visual Analog Scale (VAS) scores. Additionally, there were noticeable enhancements in the range of motion and overall quality of life for the participants.
While turmeric was part of the combination, we can't isolate its specific effects from those of the other ingredients. Nonetheless, this study suggests that combining these natural substances may offer a beneficial strategy for managing knee pain, potentially reducing the need for traditional pain medications like NSAIDs in the long run. However, further long-term studies are needed to confirm these findings.
We enrolled 100 patients with knee osteoarthritis and monitored their progress over two months. At the end of this period, we noted a significant reduction in pain levels, as evidenced by improved Visual Analog Scale (VAS) scores. Additionally, there were noticeable enhancements in the range of motion and overall quality of life for the participants.
While turmeric was part of the combination, we can't isolate its specific effects from those of the other ingredients. Nonetheless, this study suggests that combining these natural substances may offer a beneficial strategy for managing knee pain, potentially reducing the need for traditional pain medications like NSAIDs in the long run. However, further long-term studies are needed to confirm these findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 51 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Inflammation relief
87 people found this helpful
Long-term use of curcumin has effectively relieved my knee pain and inflammation post-surgery.
Read More
9
Natural anti-inflammatory
47 people found this helpful
Curcumin is a powerful natural anti-inflammatory that has helped me manage knee pain. Its effects on various inflammatory conditions, including arthritis and more, are impressive. A dosage of 1-1.5 grams is typically effective for pain relief.
Read More
9
Remarkable improvement
32 people found this helpful
I've been on curcumin for six months, and it has remarkably alleviated my knee pain. Initially, I struggled to walk, but after three months, my knee pain lessened significantly. I now take 2g daily, and I've reduced my other medications. Curcumin has made a considerable difference in my life.
Read More
9
Effective against pain
25 people found this helpful
Jarrow’s curcumin has been excellent for managing my knee pain associated with rheumatoid arthritis. I highly recommend it.
Read More
9
Pain relief strategy
9 people found this helpful
Curcumin has been remarkable for my knee pain from bone spurs. I take it every few hours during flare-ups, and the pain subsides almost entirely by the next day. It’s a fantastic remedy compared to other treatments I’ve tried.
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Frequently Asked Questions
9
Feeling much better
3 people found this helpful
I began taking curcumin for my knee pain about two weeks ago and am already feeling an improvement. I am 29 and switched from NSAIDs to dietary supplements. While NSAIDs helped, I’ve felt even better since starting curcumin and boswellia together. I ordered a second jar as I've noticed significant relief in such a short time.
9
Remarkable improvement
32 people found this helpful
I've been on curcumin for six months, and it has remarkably alleviated my knee pain. Initially, I struggled to walk, but after three months, my knee pain lessened significantly. I now take 2g daily, and I've reduced my other medications. Curcumin has made a considerable difference in my life.
9
Effective product
I have had joint problems since childhood and took non-steroidal anti-inflammatory drugs for a long time without any results. The doctor recommended curcumin, and after 3 weeks I noticed a decrease in pain and stiffness in my joints. I feel lighter and painless.
9
Inflammation relief
87 people found this helpful
Long-term use of curcumin has effectively relieved my knee pain and inflammation post-surgery.
7.5
Reduced pain noted
4 people found this helpful
I have experienced reduced pain in my rheumatoid arthritis with this product. It's essential to take it with piperine for immediate effects; otherwise, the impact is weak. I recommend this product, but limit to two capsules daily. I did increase to three for a cold but regretted it as I suffered from diarrhoea.
9
Effective against pain
2 people found this helpful
I take two capsules daily with ginger for better absorption, and it’s very effective against knee pain.
10
Knee support
1 people found this helpful
Taking this drug with RSP Nutrition's Joint Support has significantly alleviated my knee pain without side effects. I'm very satisfied with the results.
8
We assessed the effectiveness of turmeric, particularly its active ingredient curcumin, in alleviating knee pain associated with osteoarthritis (OA). This analysis included twelve studies, which involved a total of 1,438 participants, comparing those taking curcumin against placebo groups.
The findings revealed significant improvements in both pain and function for those receiving curcumin compared to the placebo group. However, there was no notable difference when curcumin was compared with other treatments like nonsteroidal anti-inflammatory drugs or paracetamol, which are commonly used for pain relief.
Additionally, we found that taking curcumin resulted in a favorable impact on inflammation markers, which can be an important aspect of managing OA symptoms. It's worth highlighting that while turmeric shows promising benefits for knee pain, further studies are needed to explore the effects of other supplements, like omega-3 and vitamin D.
The findings revealed significant improvements in both pain and function for those receiving curcumin compared to the placebo group. However, there was no notable difference when curcumin was compared with other treatments like nonsteroidal anti-inflammatory drugs or paracetamol, which are commonly used for pain relief.
Additionally, we found that taking curcumin resulted in a favorable impact on inflammation markers, which can be an important aspect of managing OA symptoms. It's worth highlighting that while turmeric shows promising benefits for knee pain, further studies are needed to explore the effects of other supplements, like omega-3 and vitamin D.
8
We investigated how curcumin, a compound found in turmeric, along with vitamin D, could affect knee pain and the progression of knee osteoarthritis (OA) in a specific rat model. In this study, male Wistar rats were divided into five groups: a control group, a group receiving curcumin, a group receiving vitamin D, a group receiving both supplements, and a sham-operated group. This well-structured approach allowed us to effectively evaluate the separate and combined impacts of these supplements.
Over a span of 12 weeks, we observed that both curcumin and vitamin D contributed to reduced pain levels on their own. When used together, their analgesic effects were even stronger, providing better pain relief for the rats. Beyond pain relief, supplemental curcumin and vitamin D also showed promising results when we examined inflammatory markers in their serum. We found a decrease in markers of inflammation while levels of the anti-inflammatory cytokine interleukin-10 (IL-10) increased.
Furthermore, we noted improvements in antioxidant levels as well as a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological analysis revealed that these supplements helped preserve joint structure and maintain cartilage integrity, while also reducing inflammation in the synovium.
Our findings emphasize the potential of curcumin and vitamin D as effective natural agents in managing knee OA and associated pain. These results could suggest a way to delay the progression of knee OA and improve patient care.
Over a span of 12 weeks, we observed that both curcumin and vitamin D contributed to reduced pain levels on their own. When used together, their analgesic effects were even stronger, providing better pain relief for the rats. Beyond pain relief, supplemental curcumin and vitamin D also showed promising results when we examined inflammatory markers in their serum. We found a decrease in markers of inflammation while levels of the anti-inflammatory cytokine interleukin-10 (IL-10) increased.
Furthermore, we noted improvements in antioxidant levels as well as a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological analysis revealed that these supplements helped preserve joint structure and maintain cartilage integrity, while also reducing inflammation in the synovium.
Our findings emphasize the potential of curcumin and vitamin D as effective natural agents in managing knee OA and associated pain. These results could suggest a way to delay the progression of knee OA and improve patient care.
9
Topical curcumin gel effectiveness
We conducted a study to explore the effectiveness of a unique topical gel infused with curcumin, a key ingredient in turmeric, for treating knee osteoarthritis. This innovative gel utilizes a self-nano-emulsifying organogel system, which allows for better delivery of curcumin, a compound known for its challenging solubility and stability issues.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
8
Curcuminoids show promise for OA
We explored how curcuminoids, the active compounds in turmeric, can help alleviate knee pain associated with osteoarthritis (OA). This study critically examined various randomized controlled trials to focus solely on the use of curcuminoids without interference from other treatments.
Our findings suggest that curcuminoids can significantly reduce pain and improve function for those dealing with symptomatic knee OA in the short term. Importantly, we saw no increase in adverse events related to their use, indicating that curcuminoids are generally safe for patients.
However, we also noticed that the quality of the existing studies varies widely, and there is significant difference among them. This variability means we should approach the recommendation of curcuminoids for a broader clinical use cautiously. Additional high-quality research will be needed to refine dosages, administration methods, and long-term safety to better inform treatment decisions for patients suffering from knee pain.
Our findings suggest that curcuminoids can significantly reduce pain and improve function for those dealing with symptomatic knee OA in the short term. Importantly, we saw no increase in adverse events related to their use, indicating that curcuminoids are generally safe for patients.
However, we also noticed that the quality of the existing studies varies widely, and there is significant difference among them. This variability means we should approach the recommendation of curcuminoids for a broader clinical use cautiously. Additional high-quality research will be needed to refine dosages, administration methods, and long-term safety to better inform treatment decisions for patients suffering from knee pain.
8
We systematically reviewed several randomized controlled trials that focused on curcumin's effects on knee pain due to osteoarthritis. Our aim was to understand how low and high doses of curcumin might aid in pain relief and improve function compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs). We gathered data from a variety of trusted medical databases, looking at studies published up until June 2021.
Our analysis included eleven studies with a total of 1,258 participants suffering from primary knee osteoarthritis. We discovered that curcuminoids, the active compounds in turmeric, provided meaningful pain relief, as shown by improvements in visual analogue scale (VAS) scores and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores when compared to other treatments.
Interestingly, we did not find significant differences in pain relief or adverse events (AEs) between high-dose (1,000 mg or more daily) and low-dose (less than 1,000 mg daily) curcumin treatments. However, curcuminoids were found to be more effective than NSAIDs in managing knee pain. While some studies reported higher adverse events in the NSAID group, only one study confirmed this finding was statistically significant.
Overall, our findings suggest that curcumin could be a beneficial supplement for those dealing with knee osteoarthritis, potentially serving as a supportive treatment alongside NSAIDs.
Our analysis included eleven studies with a total of 1,258 participants suffering from primary knee osteoarthritis. We discovered that curcuminoids, the active compounds in turmeric, provided meaningful pain relief, as shown by improvements in visual analogue scale (VAS) scores and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores when compared to other treatments.
Interestingly, we did not find significant differences in pain relief or adverse events (AEs) between high-dose (1,000 mg or more daily) and low-dose (less than 1,000 mg daily) curcumin treatments. However, curcuminoids were found to be more effective than NSAIDs in managing knee pain. While some studies reported higher adverse events in the NSAID group, only one study confirmed this finding was statistically significant.
Overall, our findings suggest that curcumin could be a beneficial supplement for those dealing with knee osteoarthritis, potentially serving as a supportive treatment alongside NSAIDs.
References
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. doi:10.3390/nu17020349
- Hidayat R, Parlindungan F, Nisa JI, Mahendra AI, Indika MI, et al. Efficacy of in relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta-analysis of clinical trials. J Rheum Dis. 2025;32:17. doi:10.4078/jrd.2024.0062
- Baharizade M, Ghetmiri SI, Mohammady M, Mohammadi-Samani S, Yousefi G. Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery. AAPS PharmSciTech. 2024;25:80. doi:10.1208/s12249-024-02789-8
- Bideshki MV, Jourabchi-Ghadim N, Radkhah N, Behzadi M, Asemani S, et al. The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses. Phytother Res. 2024;38:2875. doi:10.1002/ptr.8153
- Zhao J, Liang G, Zhou G, Hong K, Yang W, et al. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis. J Ethnopharmacol. 2024;321:117493. doi:10.1016/j.jep.2023.117493
- Valsamidou E, Amerikanou C, Tzavara C, Skarpas G, Mariolis-Sapsakos TD, et al. A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial. Heliyon. 2023;9:e20143. doi:10.1016/j.heliyon.2023.e20143
- Saber MM, Mahmoud MM, Amin HM, Essam RM. Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model. Biomed Pharmacother. 2023;166:115309. doi:10.1016/j.biopha.2023.115309
- Kamat YD, Das B, Thakkar K, Mahajan M. A Retrospective Observational Study Evaluating the Synergistic Effect of a Novel Combination of Alfapin + Native Type 2 Collagen + Mobilee (Hyaluronic Acid) + CurQlife (Curcumin) Nutraceuticals in the Symptomatic Improvement of Knee Osteoarthritis. Cureus. 2023;15:e36123. doi:10.7759/cureus.36123
- Sengupta S, Tripathi A. Evaluation of analgesic and prophylactic activity of curcumin against chikungunya-infected acute/chronic arthralgic mice. J Med Virol. 2023;95:e28661. doi:10.1002/jmv.28661
- Raj JP, Venkatachalam S, S Amaravati R. Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study. J Diet Suppl. 2024;21:28. doi:10.1080/19390211.2023.2176577
- Feng J, Li Z, Tian L, Mu P, Hu Y, et al. Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2022;22:276. doi:10.1186/s12906-022-03740-9
- Mathieu S, Soubrier M, Peirs C, Monfoulet LE, Boirie Y, et al. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms. Nutrients. 2022;14. doi:10.3390/nu14081607
- Lopresti AL, Smith SJ, Jackson-Michel S, Fairchild T. An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;14. doi:10.3390/nu14010041
- Hsiao AF, Lien YC, Tzeng IS, Liu CT, Chou SH, et al. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis. Complement Ther Med. 2021;63:102775. doi:10.1016/j.ctim.2021.102775
- Shokri-Mashhadi N, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A. A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis. Adv Exp Med Biol. 2021;1291:265. doi:10.1007/978-3-030-56153-6_16
- Dai W, Yan W, Leng X, Chen J, Hu X, et al. Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35:5921. doi:10.1002/ptr.7204
